Chronic Dose effects of Reboxetine on Motor Skill Acquisition and Cortical Excitability

Background: Enhancement of cortical excitability is thought to be potentially beneficial for synaptic plasticity as, e.g., associated with motor skill acquisition. The selective norepinephrine re-uptake inhibitor reboxetine (RBX) might therefore be able to facilitate functional recovery after brain lesions. Considering patient administration in the future we studied the effects of a chronic dose regimen on motor skill acquisition and cortical excitability. Methods: The study was randomized, double blind and placebo-controlled. 12 healthy subjects received 4mg RBX twice a day for 4 full days preceded by 2mg RBX t…