Effect of Oligodendroglial Microdomain Components on NGF Signaling

Recent results indicate that the integrity of the myelin sheath is compromised with age [1], and that myelin destruction could be a precipitating event in age-related disorders [2]. Furthermore, oligodendrocytes (OL), which furnish the CNS myelin, do not support remyelination in older animals to the same extent as in younger animals. An increased process formation reflects an OL response to NGF, however, differentially depending on age of the donor [3]. We were interested to know as to whether NGF signaling is modulated by microdomain components such as caveolin and cholesterol, which might undergo age-related c…