Changes in GABAA Receptor Subunit Distribution during Brain Maturation and Aging

Gamma-aminobutyric acid type A (GABAA) receptors are the most important inhibitory receptors in the central nervous system playing a pivotal role in the regulation of brain excitability. The pentameric receptor is usually composed of different alpha, beta, and gamma subunits which modulate the pharmacology of the receptor. Up to now, a diversity of 20 different subunits is known allowing a multitude of adaptive changes under physiological and pathophysiological conditions. In this study, we investigated the expression of five major GABAA receptors subunits (alpha1, alpha2, alpha3, alpha5, gamma2) during brain ma…