Stroke induced immunodepression syndrome (SIDS)
A Meisel, C Meisel, K Prass, E Halle, HD Volk, U Dirnagl · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Stroke patients have a high risk to develop severe bacterial infections. These infections, in particular pneumonia, have enormous impact on morbidity, mortality, and rehabilitation of these patients. Aspiration due to dysphagia, which is frequently observed after severe strokes, is a known risk factor for pneumonia. However, since aspiration alone is not sufficient for the development of pneumonia, other predisposing factors such as an impaired immune response have been postulated. Results: In a mouse model (60min middle cerebral artery occlusion), all animals develop pneumonia and sepsis spontaneous…