Premature appearance of proliferating cells in the aged rat brain following stroke
A Popa-Wagner, I Badan, I Dinca, Y Suofu, L Walker, C Kessler · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and Purpose: The age-related decline in plasticity of the rodent brain may be associated with decreased rate of neurogenesis. Since aging is both a risk factor for stroke and an impediment to recovery, we studied cellular and genetic events associated with neurogenesis after stroke in young and aged rats. Methods: Focal cerebral ischemia was produced by reversible occlusion of the right middle cerebral artery in 3 month- and 20 month-old male Sprague Dawley rats, and the functional outcome was studied at 3-, 7-, 14- and 28 days after surgery using a variety of neurological and behavioral tests. At eac…