Axonal injury, a frequent cause of central nervous system injury in bacterial meningitis
R Nau, J Gerber, S Bunkowski, W Brück · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objective: Axons in the cerebral white matter are affected in inflammatory, hypoglycemic, ischemic, traumatic and degenerative central nervous system diseases. Here we describe the contribution of white matter pathology to central nervous system injury in bacterial meningitis. Methods: 1. Various brain regions from the autopsies of five patients who died 2 to 86 days after the onset of clinical symptoms of meningitis were embedded in paraffin. 2. New Zealand White rabbits (weight 1.8–2.5kg) were infected intracisternally with 106 colony-forming units Streptococcus pneumoniae type 3 and treated with ceftriaxone 1…