CareLit Fachartikel

Effect of immunotherapy on expression of cytokines and chemokines in relation to beta-amyloid and ubiquitin in the muscles of patients with sporadic Inclusion Body Myositis (sIBM)

J Schmidt, JG Voss, R Raju, MC Dalakas · Aktuelle Neurologie · 2004 · Heft 09

Dokument
1162387
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
J Schmidt, JG Voss, R Raju, MC Dalakas
Ausgabe
Heft 09 / 2004
Seiten
–
Erschienen: 2004-09-07 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2004-833189

Zusammenfassung

Objective: To investigate treatment effects of high-dose prednisone (PRED) and intravenous immune globulin (IVIG) on inflammatory and beta-amyloid-associated proteins in muscles of sIBM patients. Background: Cytokines, chemokines and costimulatory molecules promote inflammation in sIBM. The disease pathogenesis also involves a cascade of degeneration-associated molecules such as amyloid precursor protein (APP) and ubiquitin (UBB). For reasons unknown, IVIG and PRED are ineffective in sIBM, although proven beneficial in other inflammatory muscle disorders. Methods: mRNA was extracted from muscle biopsies of sIBM…

Schlagworte

Amyloid Chemokines Cytokines After Densitometry Chemokine Tumor Aktuelle Neurologie