Regulation of Rat Heme Oxygenase–1 Gene Expression by Interleukin–6 via Jak/STAT Pathway
K Tron, A Samoylenko, G Musikowski, F Kobe, S Immenschuh, F Schaper, G Ramadori, T Kietzmann · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: Heme oxygenase–1 (HO–1) is the inducible enzyme that catalyzes oxidative degradation of heme. It has been recently shown that HO–1 expression is up-regulated in the liver by proinflammatory cytokines. However, the signal transduction pathways of the cytokine-dependent HO–1 regulation are not known in detail. Therefore, the aim of the present study was to investigate the mechanisms of the IL–6-mediated HO–1 induction. Methods: Rat primary hepatocytes (rPH) and HepG2 hepatoma cells were used as model systems. The HO–1 expression at the mRNA and protein levels was studied by Northern and Wester…
