Chronic Infection with Hepatitis B Viruses and Antiviral Drug Evaluation in UPA Mice after Liver Repopulation with Tupaia Hepatocytes
M Dandri, M Burda, K Wursthorn, J Pollok, X Rogiers, J Köck, HE Blum, F Weizsäcker, J Petersen · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background/Aim: Transplantation of primary human hepatocytes and establishment of hepatitis B virus (HBV) infection in immunodeficient urokinase plasminogen activator (uPA) transgenic mice has been shown. However, the availability of high quality primary human hepatocytes is very limited. Therefore, alternative and more accessible sources of hepatocytes permissive for in vivo HBV infection are highly desirable. Here we demonstrate the potential of primary hepatocytes from the tree shrew tupaia belangeri that were shown to be susceptible to HBV infection. Methods: Freshly isolated or cryopreserved primary tupaia…
