Mutations within the HCV Genotype 1b NS4B Protein and Correlation to Viral Replication and Initial Viral Kinetics During Interferon-alfa-Based Therapy
MW Welker, WP Hofmann, C Welsch, M Albrecht, E Herrmann, M vonWagner, S Zeuzem, C Sarrazin · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction Treatment failure to interferon (IFN)-based therapy still remains a major problem, especially for hepatitis C virus (HCV) genotype (GT)–1 infected patients. The HCV envelope (E)2 protein, the nonstructural (NS)3, and the NS5A protein have been associated with IFN resistance mechanisms. In the HCV replicon system, the most effective adaptive mutations leading to enhanced viral replication were located within the NS4B and NS5A proteins. The clinical significance of amino acid (AA) mutations within the NS4B protein in correlation with baseline HCV RNA concentration and viral decline during IFN-based th…
