Proton MR spectroscopy in patients with amyotrophic lateral sclerosis (ALS) at 3 Tesla
W Block, F Träber, O Gür, C Grothe, C Manka, R Lamerichs, J Gieseke, T Klockgether, HH Schild · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2005 · Heft 04
Bibliografische Angaben
Zusammenfassung
Purpose: The determination of upper motor neuron involvement plays a key role for the diagnosis of amyotrophic lateral sclerosis. Numbers of studies had shown, that proton MR spectroscopy (MRS) allows the detection of neurodegeneration in different brain diseases. Although these studies yielded highly significant differences between patient groups and healthy controls, the diagnosis for the individual case requires further improvement. The correct placement of the volume of interest (VOI) in MRS is important to reduce inclusion of non-target tissue. However, the VOI size used in spectroscopy studies at 1.5 T is…
