A macroarray study to evaluate differential expression of prognostic genetic markers in metastatic and locally advanced colorectal cancer

Introduction: Molecular prognostic markers are increasingly incorporated into classical staging and grading methods of clinical malignancies. DNA chip arrays represent a high-throughput tool for gene-expression studies. Tumours can be clustered upon these patterns and their biological behaviour could be more precisely described. Aim of the study: was to introduce a macroarray-based method to study differential expression of potential prognostic genetic markers in colorectal cancer. Methods: 12 patients with colorectal cancers were included in the study: 6 of them had metastatic disease at the time of analysis, w…