A new locus for restless legs syndrome maps to chromosome 4q

Three loci for RLS on chromosomes 12q, 14q and 9p (RLS-1, RLS-2 and RLS-3) have been mapped, with a recessive and autosomal-dominant mode of inheritance, respectively, but no gene has been identified so far. Investigations of further RLS families showed that there is evidence for genetic locus heterogeneity. We have conducted a genome-wide linkage analysis in a large RLS family using 400 STR markers. Linkage analysis was performed using an autosomal dominant model with a complete penetrance for homo- and heterozygotes an allele frequency of 0.003, and a phenocopy rate of 0.005. Linkage analysis revealed a new lo…