Hypometabolism in cerebellar tonsil and flocculus regions during downbeat nystagmus
P Schlindwein, C Best, S Bense, H.G Buchholz, T Siessmeier, M Schreckenberger, M Dieterich · Aktuelle Neurologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
A 66-year-old female patient presented with a 2-year history of a downbeat nystagmus syndrome (DBN) of unknown etiology with distressing oscillopsia that increased on lateral gaze or after quick head movements, and consecutive postural instability with repeated backward falls. She was examined twice by 3-D video-oculography (VOG) and 18F-fluorodeoxyglucose (FDG)-PET on and off treatment with 4-aminopyridine (4-AMP), a potassium channel blocker known to significantly improve DBN [1]. Careful neurological, neuro-physiological (electro-oculography with caloric testing, blink- and masseter reflexes), and neuro-ortho…