Differences in glucose metabolism between dementia with Lewy bodies and dementia associated with Parkinson's disease

Objectives: Post-mortem studies of patients with Parkinson's disease with dementia (PDD) and patients with Lewy body dementia (DLB) have shown both cortical Lewy bodies and Alzheimer-type pathology; however, the associated metabolic changes are not well characterized in this population. We performed 3D positron emission tomography (PET) with 18F-2-fluoro-2-desoxyglucose (18F-FDG) to determine the impact of PDD and DLB upon the regional metabolic rate of glucose (CMRglc). Methods: 18F-FDG was performed in 13 patients with PDD, 15 patients with Parkinson's disease and no dementia (PD), 16 patients with DLB and in…