Cognitive training in MS: effects and relation to brain atrophy

Objectives: Cognitive disorders are common in MS patients and no generally recommended treatment is available. Recent brain imaging studies show a considerable neuroplasticity for cognitive tasks in MS patients, but on the other hand brain atrophy already early in the disease progression. We explored the benefits of a home-based cognitive training program for memory and working memory functions in relapsing-remitting MS patients controlling for whole brain and central brain atrophy as covariates. Methods: Using a single-blinded controlled study design 42 patients were randomised into a treatment group and a cont…