CareLit Fachartikel
Effects of immunomodulatory drugs on regulatory T cells in multiple sclerosis patients and healthy individuals
M Korporal, S Möller, J Haas, B Fritz, B Wildemann · Aktuelle Neurologie · 2005 · Heft 10
Dokument
1163533
CareLit-ID
Jahr
2005
Publikation
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Metadaten
DOI
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Zusammenfassung
Background and Aims: Regulatory T cells (Treg) appear to play a crucial role in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS), although their mechanism of action is not yet understood. Recent studies have shown diverse effects of drugs on Treg, either influencing their content of FoxP3 mRNA, surface-marker pattern or their longevity. However, there is little data concerning the influence of drugs on their inhibitory capacity. Data elucidating the changes that Treg might undergo in peripheral blood of patients receiving long term treatment with immunomodulatory drugs are equally scarce,…
Schlagworte
Autoimmune Diseases
Acetate
Blood
17-Beta-Estradiol
Antigen-Presenting Cells
Address
Aktuelle Neurologie
