Investigating the role of BNIP3 and NIX in resistance of glioblastoma cells against hypoxia-induced apoptosis

Objectives: Glioblastoma multiforme (GBM) is among the most hypoxic tumors known and the oxygenation status of GBMs is negatively correlated with their therapy resistance, although the molecular mechanisms of this correlation remain largely unidentified. The aim of this study was to 1) analyze the variations of different glioblastoma cell lines in resistance to hypoxia-induced cell death, to 2) investigate the functional integrity of hypoxia-induced apoptotic signaling pathways in these cell lines and to 3) evaluate the relevance of alterations in apoptotic signaling for hypoxia resistance of GBM. Methods: Trans…