CB1 and TRPV1 receptors mediate protective effects on electrophysiological properties during colonic inflammation
A Sibaev, F Massa, B Yüce, G Marsicano, HA Lehr, B Lutz, B Göke, HD Allescher, M Storr · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: CB1 and TRPV1 receptors modulate enteric neurotransmission and colonic inflammation in the GI-tract. Colitis was shown to be more fulminant in CB1-/- and TRPV1-/- mice. Aim: The aim of the present study was to investigate electrophysiological changes on resting membrane potential (RMP) and enteric neurotransmission in inflamed distal colon of mice and additionally in receptor deficient mice which are more susceptible to colitis. Methods: Colitis was induced with DNBS. Electrophysiological properties were evaluated at 8 and 24 hours after DNBS treatment. Intracellular recording techniques were used to recor…
