CareLit Fachartikel
Antibodies to Human Calreticulin in Primary Biliary Cirrhosis are Epitope Specific
W Kreisel, KW Rösler, J Riedel, H Hoschützki · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Dokument
1163578
CareLit-ID
Jahr
2006
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Metadaten
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Zusammenfassung
Aims: Autoimmune liver diseases are characterized by clinical symptoms, specific liver histology and characteristic autoantibodies. We had previously shown that sera from patients with autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) contain antibodies to the endoplasmic reticulum stress protein calreticulin (CRT). In AIH they are mainly of the type IgG, whereas in PBC the types IgA and IgM predominate. We investigated the epitope specificity of antibodies to CRT in order to find out whether AIH and PBC can be differentiated by epitope-specific anti-CRT antibodies. Methods: 138 overlapping octapept…
Schlagworte
Antibodies
Calreticulin
Autoimmune Hepatitis
Hepatitis
Autoantibodies
Amino Acids
Zeitschrift für Gastroenterologie
