Hepatic fibrosis in patients with chronic hepatitis B virus infection can be partially reversed by IFN-γ
S Dooley, BE Wang, JD Jia, WF Wu, JZ Xian, AM Gressner, PR Mertens, WM Cai, HL Weng · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background. Hepatic fibrosis due to chronic hepatitis B virus (HBV) infection has an enormous socio-economic impact. Besides strategies aiming at virus elimination, prevention or reversal of liver fibrosis is amenible. Given the antifibrotic activity of IFN-γ, a randomized open-labeled multicenter trial was initiated to test IFN-γ in HBV infection. Methods. HBs-antigen positive patients with biopsy proven hepatic fibrosis (n=99, stages 2–4 according to Scheuer criterion) were treated with diammone glycyrrhizinate and potassium magnesium aspartate.Treatment with 50g IFN-γ i.m. on a daily basis for three months an…
