The Expression of Angiotensin Converting Enzyme (ACE) in Tumor Cells may Increase Invasive Ability and Promote Lymph Node Metastases
S Carl-McGrath, U Lendeckel, U Lendeckel, P Malfertheiner, P Malfertheiner, M Ebert, A Rössner, C Röcken · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: ACE cleaves angiotensin I to form angiotensin II, which is involved in the regulation of growth and differentiation via the angiotensin II receptors, Type 1 (AT1) and Type 2 (AT2). ACE is up-regulated in gastric cancer, and the increased mRNA expression associated with the ACE polymorphism significantly correlates with the development of lymph node metastases in gastric cancer. Methods: Using immunohistochemistry, we investigated the expression of ACE in lymph node metastases of gastric cancer. Gastric cancer cell lines were evaluated for the mRNA expression of ACE, AT1, and AT2, and in vitro cell prolifer…
