CareLit Fachartikel
Regulation of hepcidin expression in HepG2 cells
E Fein, D Harrison-Findik, W Stremmel, H Kulaksiz · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Dokument
1163593
CareLit-ID
Jahr
2006
Publikation
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Zusammenfassung
Background & Aims: The hepatic peptide hepcidin is proposed to be a central regulator of iron homeostasis. Hepcidin acts as negative regulator of intestinal iron absorption and of iron release from macrophages. It also exhibits antimicrobial acvtivity as a type II acute-phase reactant. We have analysed the regulation of hepcidin expression in the human hepatoma cell line, HepG2 cells, by iron, deferoxamine (DFO), interleukin–6 (IL–6), lipopolysaccaride (LPS), and ethanol. Methods: Hepcidin mRNA expression was shown by RT-PCR experiments. Specific hepcidin antibodies were raised against N-terminal and C-terminal…
Schlagworte
Alcohol Dehydrogenase
Deferoxamine
Absorption
Antibodies
Anemia
Zeitschrift für Gastroenterologie
