Expression und prognostische Bedeutung von DNA-Reparaturproteinen beim kolorektalen Karzinom – BRCA-1 und ATM als neue unabhängige Prognose-faktoren

Aims: Failure of DNA double strand break repair may result in chromosomal instability, a common phenomenon in colorectal cancer. The expression pattern of DNA double strand break repair proteins and their putative prognostic value have not been investigated in detail in colorectal cancer. Methods: The expression of DNA DSB repair proteins ATM, BRCA1, BRCA2, Ku70 and Ku80 was investigated by immunohistochemistry in a series of 342 sporadic colorectal carcinomas and compared with clinicopathological data, patient survival, as well as expression of Ki67 and mismatch repair proteins MLH1 and MSH2. Results: Expressio…