CareLit Fachartikel
Mucosal antimicrobial peptides accumulate in airway mucus
K Felgentreff, C Beisswenger, M Griese, R Bals · Pneumologie · 2006 · Heft 01
Dokument
1163753
CareLit-ID
Jahr
2006
Publikation
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Metadaten
DOI
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Zusammenfassung
Background: Antimicrobial peptides (AMPs) and mucins are components of the airway secretions and both contribute to the innate host defense system of the lung. Antimicrobial peptides (AMPs) are effector molecules of the innate immune system, which lyse microbial cells by interaction with biomembranes. Besides their direct antimicrobial function, they have multiple roles as mediators of inflammation. The principal families of AMPs expressed in the lung are the defensins and the cathelicidins. One of the prominent physical features of AMPs is their strong positive charge at neutral pH. Mucins are macromolecular mo…
Schlagworte
Bronchoalveolar Lavage Fluid
Bronchoalveolar Lavage
Acetylgalactosamine
Cathelicidins
Defensins
Pneumologie
