CareLit Fachartikel
Crosstalk between glucocorticoid receptor bound corticosteroids and the TGF-β-Smad 3 pathway in liver cells
U Bolkenius, D Hahn, AM Gressner, K Breitkopf, L Wickert · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Dokument
1163891
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Jahr
2006
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Zusammenfassung
Aims: The plasma level of corticosteroids in patients suffering from liver fibrosis is elevated as a result of reduced steroid catabolism. TGF-β signalling activates hepatic stellate cells (HSC) and promotes the development of liver fibrosis. Recent studies indicate that glucocorticoids and their receptors (GR) seem to antagonize TGF-β effects by interacting with the TGF-β-Smad pathway. However, the underlying mechanisms that mediate corticosteroid-TGF-β-interaction have not been clarified yet. Methods: We studied the influence of glucocorticoids and mineralocorticoids on the TGF-β mRNA expression, TGF-β secreti…
Schlagworte
TGF-β-Smad 3 pathway
corticosteroid
hepatic stellate cell
Dexamethasone
Aldosterone
Biology
Zeitschrift für Gastroenterologie
