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Expression and TGF-beta modulation of connective tissue growth factor (CTGF) in hepatic stellate cells and hepatocytes

AM Gressner, B Lahme, O Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2006 · Heft 01

Dokument
1163892
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
AM Gressner, B Lahme, O Gressner, R Weiskirchen
Ausgabe
Heft 01 / 2006
Seiten
–
Erschienen: 2006-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2006-931639

Zusammenfassung

Background: CTGF, a heparin binding 38 kd cysteine-rich peptide is well known as a secreted, TGF-β regulated down-stream TGF-β effector molecule, which is strongly expressed in fibrotic liver tissue, especially in fibrogenic hepatic stellate cells (HSC) and myofibroblasts (MFB). CTGF is suggested to play an important role as a positive trap for TGF-β by facilitating its receptor binding and as a negative trap for BMP7, thus, contributing extracellularly to a functional imbalance in favour of fibrogenesis. Aim of the present study was (i) to analyze CTGF expression and regulation in HSC and hepatocytes (PC) and (…

Schlagworte

CTGF Fibrose Mediatoren TGF-beta Connective Tissue Growth Factor Connective Tissue Cysteine Zeitschrift für Gastroenterologie