CareLit Fachartikel
Hepatocyte-specific loss of manganese superoxide dismutase causes liver failure
J Lenart, F Dombrowski, T Kietzmann · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Dokument
1163895
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
In the mitochondrial matrix manganese superoxide dismutase (MnSOD) is the essential antioxidant enzyme that converts O2 ●- to H2O2 which can then be converted to water by glutathione peroxidase. The liver has the highest specific MnSOD activity, which implies its important role for maintaining proper organ function and to prevent pathological situations such as cancer. In line with this, it was proposed that the MnSOD gene may act as a tumor suppressor gene. However, the exact molecular mechanism by which this antioxidant enzyme suppresses the malignant cellular phenotype has not yet been elucidated. Therefore,…
Schlagworte
MnSOD
hepatocytes
liver faiulure
Alkaline Phosphatase
Bilirubin
Allele
After
Tumor
Zeitschrift für Gastroenterologie
