CareLit Fachartikel
REDIRECTION OF T CELLS AGAINST HBV INFECTED CELLS USING SINGLE CHAIN ANTIBODY FRAGMENTS
F Bohne, E Gückel, T Kürschner, A Schulze, S Urban, H Abken, U Protzer · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Dokument
1163901
CareLit-ID
Jahr
2006
Publikation
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Metadaten
DOI
ja
zitierfähig
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Zusammenfassung
Background: Worldwide about 350 million individuals suffer from chronic HBV infection and are at risk to develop hepatocellular carcinoma or liver cirrhosis. Upon antiviral therapy, viral replication is stopped, but the viral genome is rarely eliminated, and HBV surface antigen is still produced by infected cells. Thus, a potent artificial T cell response resulting in killing of residual infected cells, could be a promising addition to antiviral medication. The aim of our work therefore is to establish T cells with chimeric T cell receptors (TCRs) to target HBV infected hepatocytes. Methods: Single chain fragmen…
Schlagworte
Hepatitis B
Immuntherapie
Antigens
Work
After
Hepatitis
Zeitschrift für Gastroenterologie
