Stimulus-intensity dependence of the EEG-response to transcranial magnetic stimulation (TMS)

Introduction: Transcranial magnetic stimulation (TMS) elicits an EEG response which has been suggested recently as a direct marker of cortical excitability. We examined the development of the EEG response to TMS in children and its relationship to peripheral indexes of cortical excitability (motor evoked potential, MEP amplitude). Methods: We applied single pulse TMS to the non-dominant motor cortex of 6–10-year-old children and adult subjects and determined the TMS-evoked N100-amplitude in DC EEG recordings. Amplifier deblocking was employed. A forewarned reaction time task served to investigate the influence o…