Amygdala and prefrontal cortex emotional processing in panic disorder influenced by catechol-O-methyltransferase val158met genotype
K Domschke, P Ohrmann, M Braun, T Suslow, J Bauer, C Hohoff, A Kersting, A Engelien, V Arolt, W Heindel, H Kugel, J Deckert · Klinische Neurophysiologie · 2006 · Heft 03
Bibliografische Angaben
Zusammenfassung
Introduction: Panic disorder is an anxiety disorder with an estimated heritability of up to 48%. The functional val158met (472G/A) polymorphism in the gene coding for the catechol-O-methyltransferase (COMT) has repeatedly been found to be associated with the disorder. Additionally, in a recent fMRI study the COMT val158met polymorphism has been shown to influence limbic and prefrontal brain activation in response to unpleasant stimuli (Smolka et al., 2005). Consequently, neuronal activation patterns following emotional stimulation were used as an endophenotype and investigated for association with the COMT val15…
