Voxel-Guided Morphometry reveals discordance between progressive delayed brain atrophy and clinical recovery after middle cerebral artery infarction

Middle cerebral artery (MCA) infarctions cause severe neurological deficits like hemiparesis and aphasia. Usually, the maximum of neurological symptomatology is reached in the first hours after stroke onset, followed by clinical improvement in the subsequent time. Little is known about the relation of clinical and structural consequences of cerebral infarcts. In this study, we studied the interrelationship between long-term development of brain volume alterations in humans suffering from MCA infarction and the clinical outcome within the same time period. Ten Patients were scored (European Stroke Score (ESS)) wh…