A thirty-year war against Helicobacter pylori: a personal reflection

The author personal results include therapeutic trials, the first Hungarian monograph on H. pylori, meta-analysis of the national and European eradication results and the first quality of life study in H. pylori-related functional dyspepsia. Less known are the interactions between H. pylori, carbonic anhydrase (CA) and its inhibitors. Gastric CA was described in 1939 by Horace W. Davenport. With the availability of acetazolamide in 1952 it was shown that it inhibits acid secretion in humans and dogs. Ioan Puca, from Szilágysomlyó, Romania, observed first, that in patients with chronic pulmonary obstructive disea…