The behaviour of matrix metalloproteinase-9, hepatocyte growth factor receptor and insulin-like growth factor receptor-I expressions in ulcerative colitis

Background: Epithelial cell growth regulation has been reported to be altered in inflammatory bowel disease. Matrix metalloproteinases play an important part in extracellular matrix remodelling. Hepatocyte growth factor receptor (c-met) and insulin-like growth factor receptor-I (IGFR-1) modulate intestinal epithelial cell proliferation and migration, play a role in regenerative processes and intestinal wound healing. Aim: Determination of protein expression levels and mRNA of matrix metalloproteinase-9 (MMP-9), c-met and IGFR-1 in correlation with the severity of inflammation in ulcerative colitis (UC). Material…