Effects of glucocorticoids in the L-arginine-induced acute pancreatitis: the mechanism of NF-KB activation

Introduction: The effects of glucocorticoids on acute pancreatitis (AP) have remained contradictory. The aims of the present study were 1. to investigate the consequences of an exogenous glucocorticoid agonist (methylprednisolone – MP) and a glucocorticoid antagonist (RU-38486– RU) treatment on local and systemic responses to L-arginine-induced acute pancreatitis in rats, and 2. to gain an insight into the role of NF-κB activation and macrophage inhibitory factor (MIF) release in glucocorticoid action. Materials and Methods: Male Wistar rats weighing 250–300g were used. Acute pancreatitis was induced by intraper…