Effects of probiotics, mesalazin and methylprednisolon on indomethacin provoked bowel inflammation in rats

Aim: The effectiveness of probiotics in preserving intestinal mucosa integrity has been already affirmed, although in case of Crohn's disease is not yet clarified. We have analyzed how the effective probiotics (ProGastro) are compared to drugs used in clinical practice in preventing the development of inflammation induced by indomethacin in rats. To confirm the macroscopic findings, we have measured the levels of TNF alpha in sera and in stimulated samples. Methods: Bowel inflammation has been provoked by given indomethacin five s.c. in 10mg/kg doses once daily for three days to four groups of Wistar rats. To pr…