Nutritional components and their influence on the pathogenesis of murine autoimmune diabetes in early life

Introduction: Diet can influence the development of autoimmune diabetes. Due to the complexity of diets, it is difficult to determine if associations with diabetes can be attributed to single components. The aim of this study was to develop basal diabetogenic and non-diabetogenic diets that can be used to test the influence of specific dietary components on diabetes incidence in the NOD mouse. Method: The reference diet used was Altromin 1324 which contains various protein sources (wheat, wheat bran, wheat middling, soy, barley, corn, fish meal, whey, lupin). Three isocaloric isonitrogenic basal diets with a 16%…