CareLit Fachartikel

Influence of NOD2/CARD15 gene polymorphisms on the susceptibility to collagenous colitis

A Madisch, S Hellmig, S Schreiber, B Bethke, M Stolte, S Miehlke · Zeitschrift für Gastroenterologie · 2006 · Heft 09

Dokument
1164450
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Madisch, S Hellmig, S Schreiber, B Bethke, M Stolte, S Miehlke
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-19 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2006-950679

Zusammenfassung

Aims: Collagenous colitis is a chronic inflammatory bowel of unknown origin. In some cases inflammatory bowel disease-like histomorphological features such as active crypt inflammation or Paneth cell metaplasia are found. Recently, it has been shown that the NOD2/CARD15 gene is strongly associated with susceptibility to Crohn's disease and NOD2 expression in Paneth cells is increased and also evident in metaplastic Paneth cells in the colon of patients with inflammatory bowel disease. Aims: to assess the functional NOD2/CARD15 polymorphisms in a case-control setting for the susceptibility to collagenous colitis.…

Schlagworte

Allele Blood Donors Germany Blood Association Zeitschrift für Gastroenterologie