CareLit Fachartikel
Functional integration of primary human hepatocytes after transplantation into upa mice
T Volz, M Lütgehetmann, JM Pollok, L Fischer, A Quaas, M Dandri, J Petersen · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Dokument
1164456
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background/Aim: Immunodeficient uPA mice containing livers repopulated with primary human hepatocytes provide a small in vivo model for studies on human hepatotropic viruses (Dandri et al, Hepatology 2001; J Hepatol 2005). However, repopulation levels >25% with human hepatocytes are rare in this system. To improve transplantation efficacy we investigated cell functions of the human hepatocytes within the xenogenic environment and cell-cell interactions. Methods/ Results: By immunohistochemistry, expression of human Albumin, alpha-1 Antitrypsin, P450 and transcription factor HNF4 were detected and indicated well…
Schlagworte
After
Transplantation
Alpha-1-Antitrypsin
alpha 1-Antitrypsin
Desmosomes
Actin
Zeitschrift für Gastroenterologie
