Inhibition of immune activation, impairing either the cellular (thymectomy) or the cytokine respone (application of anti-inflammatory cytokine G-CSF), is enhancing liver regenerat…

Recently, we raised the hypothesis, that liver regeneration is inversely correlated with parameters of immune activation. This was the reason to test on one hand the effect of thymectomy, which is impairing T-cell maturation and subsequent T-cell activation. As GCSF was reported to have anti-inflammatory activity affecting cytokine release, the effect of the perioperative treatment with GCSF on liver regeneration was investigated in a second approach. Rats were subjected to 90% partial hepatectomy. Animals were sacrificed 24h, 48h and 7 days after resection. Besides the survival time and rate, read-out parameter…