Significance of HBsAg and HDVRNA levels in patients with delta hepatitis recruited in the Hep-Net/International HDV intervention trial
K Zachou, C Yurdaydin, U Drebber, G Dalekos, A Erhardt, Y Cakaloglu, H Degertekin, S Gurel, S Zeuzem, H Bozkaya, V Schlaphoff, HP Dienes, T Bock, MP Manns, H Wedemeyer · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Hepatitis delta virus (HDV) infection is associated with severe liver disease with limited treatment options. We investigated the significance of HDV-RNA, HBsAg and HBV-DNA levels and analysed histological, biochemical and demographic parameters in patients recruited in an International-multicenter intervention trial. Methods: 91 patients with chronic HDV infection were randomized (39 in Turkey, 43 in Germany and 9 in Greece). 85 sera were available for HDV-RNA, HBsAg and HBV-DNA quantification. Blinded histological grading and staging (Ishak-score) was performed by the Hep-Net central pathologist. Results…
