The association of immune activation with symptoms and psychiatric comorbidity in irritable bowel syndrome
T Liebregts, B Adam, C Bredack, A Roth, S Lester, S Downie-Doyle, E Smith, P Drew, N Talley, G Holtmann · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Transient inflammation is known to precipitate the manifestation of irritable bowel syndrome (IBS) but there are limited data on the link between immune function and symptoms. We therefore aimed to characterize basal and LPS- induced cytokine production in peripheral blood mononuclear cells (PBMC) of IBS patients and correlate symptoms with immunologic function. Methods: PBMC from 55 IBS patients (18 Mixed-, 17 Constipation-, 20 Diarrhea- predominant) and 36 healthy controls (HC) were isolated by density gradient centrifugation and cultured for 24 hours with or without (1ng/ml) E. coli LPS. Cytokine produc…
