Initial experiences utilizing perfusion CT in the follow-up of patients with gastrointestinal stromal tumors under imatinib mesylate treatment

Introduction: Imatinib mesylate is a specific tyrosine kinase inhibitor with high activity against gastrointestinal stromal tumors (GIST) and anti-angiogenic effects. Perfusion studies might help reveal early signs of recurrence. Aim of this study is the optimization of the CT perfusion protocol and evaluation of perfusion patterns of metastatic GIST lesions under therapy. Material and Methods: 20 patients with metastatic GIST under Imatinib mesylate treatment were evaluated using a 64 slice CT scanner. Perfusion CT of metastatic lesions was carried out utilizing the following optimized parameters: Delay 6s (liv…