Volumetry of ultrasound images of orthotopic tumours in a xenotransplantation model in mice
C Heneweer, D Becker, B Schniewind, S Tiwari, O Ammerpohl, D Emme, C Graeff, M Both, CC Glueer, H Kalthoff, M Heller · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2008 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Valid determination of tumour growth represents one of the basic prerequesites e.g. in drug therapy studies. The aim of the present project was to investigate whether small animal ultrasound is able to provide robust data in an orthotopic xenotransplantation model in mice with partly complex intraabdominal conditions. Material and Methods: 1×106 cells of the human pancreatic cancer cell line PancTu I were injected orthotopically in 8 SCID beige mice. Animals were investigated on postoperative days 9, 17, and 31. We used a Vevo 770 small animal ultrasound device equipped with a 706 scanhead (Visuals…
