Substantia nigra hyperechogenicity and CSF dopamine depletion in HIV
J Thiermann, M Obermann, M Küper, O Kastrup, Ö Yaldizli, S Esser, E Koutsilieri, H.C Diener, M Maschke · Aktuelle Neurologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Clinical manifestations of dopaminergic dysfunction are prominent findings in patients with human immunodeficiency virus (HIV) infection and consecutive HIV dementia. Decreased cerebrospinal fluid (CSF) dopamine (DA) levels and neuronal loss in the substantia nigra (SN) have been reported in HIV infected patients suggesting nigrostriatal damage. Structural changes detectable as hyperechogenicity in transcranial ultrasound (TCS) of the SN were reported in patients with Parkinson's disease (PD) and other neurological conditions. Objective: In this study we assessed the echomorphology of the SN in diffe…
