CareLit Fachartikel

Delay and reduction of glial scar formation after spinal cord injury by systemic cyclooxygenase blockade

J.M Schwab · Aktuelle Neurologie · 2008 · Heft 09

Dokument
1164638
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
J.M Schwab
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-02 00:00:00
ISSN
0302-4350
DOI
10.1055/s-0028-1086639

Zusammenfassung

Disturbances in microcirculating and inflammation promotes glial scar formation after spinal cord injury. Cyclooxygenases (COX) are key enzymes in the conversion of arachidonic acid into prostanoids which mediate immunomodulation, mitogenesis, apoptosis, blood flow and inflammation. We investigated the impact of CNS effective COX pathway inhibition in (Indomethacin, 2mg/kg/d, i.p.) on glial scar formation (reactive astrogliosis, extracellular matrix (ECM) deposition) by immunohistochemistry following experimental spinal cord injury in rat. Pan-COX inhibition (COX-1, COX-2) resulted in significantly (p

Schlagworte

After Astrocytes Arachidonic Acid Apoptosis Blood Aktuelle Neurologie