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ZK200775, ZK187638, ZK238519 and ZK166350: comparison of different potent antagonists of AMPA-type glutamate receptor channels and their potential role for neuroprotection

M Borngräber, F Schlesinger, S Petri, R Dengler, K Krampfl · Aktuelle Neurologie · 2008 · Heft 09

Dokument
1164640
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
M Borngräber, F Schlesinger, S Petri, R Dengler, K Krampfl
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-02 00:00:00
ISSN
0302-4350
DOI
10.1055/s-0028-1086659

Zusammenfassung

Neurodegeneration in several diseases like amyotrophic lateral sclerosis is at least in part caused by chronic excitotoxicity. AMPA-receptor-mediated fast excitatory synaptic transmission induces an increase of the intracellular calcium-concentration, that might explain one pathway in the pathophysiological model of chronical excitotoxicity. Therefore, neuroprotection by antagonising AMPA-receptor mediated synaptic transmission by selective AMPA-type-receptor blockers is a promising strategy albeit AMPA-type-receptor blockers show a lot of (neuro)toxic side effects. An urgent aim of drug design is to develop mor…

Schlagworte

AMPA Drug Design Amyotrophic Lateral Sclerosis Computer Simulation Computer Calcium Aktuelle Neurologie