CareLit Fachartikel
Influence of cerebrospinal fluid on survival and differentiation of foetal rat neural stem cells
J Buddensiek, A Dressel, A Storch, M Sabolek · Aktuelle Neurologie · 2008 · Heft 09
Dokument
1164646
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Zusammenfassung
Background: Neural stem cells (NSCs) are a promising source for cell replacement therapies. Intraventricular administration of NSCs offers a non-traumatic transplantation method into the CNS. Recently has been demonstrated that human NSCs injected into the Cisterna magna of an ALS mouse model did not migrate into brain tissue in sufficient amount. A negative influence of cerebrospinal fluid (CSF) on the survival rate of NSCs was discussed. Here, we studied the behaviour of rodent foetal NSCs (rfNSCs) in CSF during expansion and differentiation. Methods: Proliferation, differentiation and survival rate of rfNSCs…
Schlagworte
After
Astroglia
Cisterna Magna
Lead
Transplantation
Aktuelle Neurologie
