RNA Signatures of multiple sclerosis patients disclose consistent gene expression changes after 2 years of interferon beta 1a sc therapy

Objective: This longitudinal systematic gene expression study focuses on multiple sclerosis (MS) and the effects of medication by recombinant Interferon-beta-1a (IFNb1a). It is the aim to infer accessory regulatory pathways of the applied drug and to detect surrogate markers for therapeutic intervention in human PBMCs. Interferon beta (IFNb) therapy in MS patients has proven efficacious, but still the underlying molecular mechanisms remain unclear. Large scale analysis of peripheral blood gene transcripts over time provide with the complexity of MS and generates a huge data set that shall serve molecular group c…