GSK-3beta activation mediates Abeta induced tau pathology in multiple transgenic mice

Alzheimer's disease (AD) is a complex disorder neuropathologically characterized by extra- and/or intracellular aggregation of toxic Abeta peptide and tau protein species, neuroinflammation, neuronal and synaptic loss. Toxic Abeta species are considered to be upstream in the etiopathological mechanism. We could mimic all neuropathological characteristics except for the tau pathology in mutant V717I amyloid precursor protein (APP-V717I) overexpressing mice. This mutation causes a familial form of AD in patients. In order to have a more complete animal model we overexpressed APP-V717I and tau-P301L protein in mice…